Hypoglycemic, antioxidant and hypolipidemic activity of Asparagus racemosus on streptozotocin-induced diabetic in rats

The potential role of the ethanolic extract of Asparagus racemosus (Wild) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin induced diabetic rats. Oral administration of ethanolic extract of Asparagus racemosus (EEAR) 200 and 400 mg/kg/b.w for 21 days significantly decreased the blood glucose level, fluid intake and considerably increased the body weight of diabetic induced rats. EEAR significantly decreased thiobarbituric acid reactive substances and significantly increased in reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 21 days of treatment. The study also investigated the antihyperlipidemic potential of EEAR. The results show that the EEAR is promising for development of standardized phytomedicine for the treatment of diabetes mellitus.